Thyroid Dysfunction in Dysfunctional Uterine Bleeding

Abnormal uterine bleeding is a frequent debilitating symptom resulting in unnecessary, incorrect and expensive treatment and invariably ends up in surgical treatment with its attendant risk of morbidity and mortality. It occurs in 9-14% of women between menarche and menopause, significantly impacting quality of life and imposing financial burden (3). After excluding the structural causes of AUB (abnormal uterine bleeding) most cases are associated with failure of ovulation and consequent hormonal imbalance. Ovarian dysfunction may be caused by either a primary defect or pathological lesion within the ovary itself or may be secondary to malfunction of other endocrine glands notably hypothalamus, pituitary and thyroid (4).